|Reactivity||Human, Rat, Rabbit, Horse, Dog|
|Predicted||Human, Rat, Rabbit, Horse, Dog|
|Other Names||cAMP and cAMP-inhibited cGMP 3', 5'-cyclic phosphodiesterase 10A, 126.96.36.199, 188.8.131.52, PDE10A|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-PDE10A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PDE10A Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.|
|Cellular Location||Cytoplasm. Note=Located mostly to soluble cellular fractions|
|Tissue Location||Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.|
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Provided below are standard protocols that you may find useful for product applications.
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
Kotera J.,et al.Biochem. Biophys. Res. Commun. 261:551-557(1999).
Fujishige K.,et al.J. Biol. Chem. 274:18438-18445(1999).
Loughney K.,et al.Gene 234:109-117(1999).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
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