|Alias Symbol||FBXO22, FBX22,|
|Other Names||F-box only protein 22, F-box protein FBX22p44, FBXO22, FBX22|
|Format||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.|
|Reconstitution & Storage||Add 50 &mu, l of distilled water. Final Anti-FBX22 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FBX22 Antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.|
|Cellular Location||Cytoplasm, myofibril, sarcomere, Z line|
|Tissue Location||Predominantly expressed in liver, also enriched in cardiac muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Tan P.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Cenciarelli C.,et al.Curr. Biol. 9:1177-1179(1999).
Gauci S.,et al.Anal. Chem. 81:4493-4501(2009).
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