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DMRT1 antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • WB - DMRT1 antibody - N-terminal region AI16234

    WB Suggested Anti-DMRT1 Antibody Titration: 0.2-1 μg/ml
    Positive Control: Human brain
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Y5R6
Other Accession NM_021951, NP_068770
Reactivity Human, Rabbit, Pig, Bovine, Dog
Predicted Human, Rabbit, Pig, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 39kDa
Additional Information
Gene ID 1761
Alias Symbol DMT1
Other Names Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1, DMRT1, DMT1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-DMRT1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsDMRT1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DMRT1
Synonyms DMT1
Function Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070}.
Tissue Location Testis-specific. Expressed in prostate cancer (at protein level).
Citations (0)
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Background

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

References

Raymond C.S.,et al.Hum. Mol. Genet. 8:989-996(1999).
Calvari V.,et al.Genomics 65:203-212(2000).
Cheng H.H.,et al.Cell Res. 16:389-393(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 389.00
Cat# AI16234
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