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GATA1 antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P15976 |
| Other Accession | NM_002049, NP_002040 |
| Reactivity | Human, Mouse, Rat, Rabbit, Sheep, Bovine, Guinea Pig, Dog |
| Predicted | Human, Mouse, Rat, Rabbit, Sheep, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Gene ID | 2623 |
|---|---|
| Alias Symbol | ERYF1, GF1, NFE1, GF-1, XLTT, GATA-1 |
| Other Names | Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein, GATA1, ERYF1, GF1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GATA1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GATA1 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GATA1 |
|---|---|
| Synonyms | ERYF1, GF1 |
| Function | Transcriptional activator or repressor which serves as a general switch factor for erythroid development (PubMed:35030251). It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). |
| Cellular Location | Nucleus. |
| Tissue Location | Erythrocytes.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.
References
Trainor C.D.,et al.Nature 343:92-96(1990).
Zon L.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:668-672(1990).
Ross M.T.,et al.Nature 434:325-337(2005).
Calligaris R.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:11598-11602(1995).
Boyes J.,et al.Nature 396:594-598(1998).
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