MAX antibody - N-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P61244 |
Other Accession | NM_145112, NP_660087 |
Reactivity | Human, Mouse, Rat, Dog |
Predicted | Human, Mouse, Rat, Chicken, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 17kDa |
Gene ID | 4149 |
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Alias Symbol | MGC10775, MGC11225, MGC18164, MGC34679, MGC36767, orf1, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 |
Other Names | Protein max, Class D basic helix-loop-helix protein 4, bHLHd4, Myc-associated factor X, MAX, BHLHD4 |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MAX antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | MAX antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAX (HGNC:6913) |
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Synonyms | BHLHD4 |
Function | Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. |
Cellular Location | Nucleus. Cell projection, dendrite. |
Tissue Location | High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity.
References
Blackwood E.M.,et al.Science 251:1211-1217(1991).
Vaestrik I.,et al.Oncogene 8:503-507(1993).
Maekelae T.P.,et al.Science 256:373-377(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Heilig R.,et al.Nature 421:601-607(2003).
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