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CNR2 / CB2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - CNR2 / CB2 Antibody (Internal) ALS10013
    Anti-CNR2 / CB2 antibody IHC of human tonsil.
    detail
  • IHC - CNR2 / CB2 Antibody (Internal) ALS10013
    Anti-CNR2 / CB2 antibody ALS10013 IHC of human germinal center and mantle zone.
    detail
  • IHC - CNR2 / CB2 Antibody (Internal) ALS10013
    Anti-CNR2 / CB2 antibody IHC of human Brain, Glioblastoma.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P34972
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Dilution IHC-P (5-10 µg/ml)
Additional Information
Gene ID 1269
Other Names Cannabinoid receptor 2, CB-2, CB2, hCB2, CX5, CNR2, CB2A, CB2B
Target/Specificity Human CNR2 / CB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PROS1 (47%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCNR2 / CB2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CNR2
Synonyms CB2A, CB2B
Function Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Perikaryon Note=Localizes to apical dendrite of pyramidal neurons.
Tissue Location Preferentially expressed in cells of the immune system with higher expression in B-cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root ganglion sensory neurons (at protein level). Two isoforms are produced by alternative promoter usage and differ only in the 5' UTR: isoform CB2A is observed predominantly in testis with some expression in brain, while isoform CB2B is predominant in spleen and leukocytes
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

References

Munro S.,et al.Nature 365:61-65(1993).
Liu Q.-R.,et al.Genes Brain Behav. 8:519-530(2009).
Bruess M.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Warren C.N.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Saravanan T.,et al.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS10013
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