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APLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - APLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain) ALS10021
    Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - APLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain) ALS10021
    Anti-APLNR/ Apelin Receptor / APJ antibody IHC of human Brain, Glioblastoma.
  • IHC - APLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain) ALS10021
    Anti-APLNR/ Apelin Receptor / APJ antibody IHC of human Colon, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P35414
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (10-20 µg/ml)
Additional Information
Gene ID 187
Other Names Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11, APLNR, AGTRL1, APJ
Target/Specificity Human Apelin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsAPLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APLNR
Synonyms AGTRL1, APJ
Function Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936).
Cellular Location Cell membrane. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753) {ECO:0000250|UniProtKB:Q9JHG3, ECO:0000269|PubMed:25639753}
Tissue Location Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753). Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753).
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

References

O'Dowd B.F.,et al.Gene 136:355-360(1993).
Eggerickx D.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS10021
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