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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GPCRW / GPR18 Antibody (Extracellular Domain)   

GPCRW / GPR18 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

  • IHC - GPCRW / GPR18 Antibody (Extracellular Domain) ALS10030
    Anti-GPR18 antibody ALS10030 IHC of human testis, seminiferous tubule.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14330
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 2841
Other Names N-arachidonyl glycine receptor, NAGly receptor, G-protein coupled receptor 18, GPR18, GPCRW
Target/Specificity Human GPR18. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPCRW / GPR18 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR18
Synonyms GPCRW
Function Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane
Tissue Location Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937). Most abundant in testis and spleen (PubMed:16844083). Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083)
Volume 50 µl
Research Areas
Citations (0)

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Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system.


Gantz I.,et al.Genomics 42:462-466(1997).
Kohno M.,et al.Biochem. Biophys. Res. Commun. 347:827-832(2006).
Xu X.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Dunham A.,et al.Nature 428:522-528(2004).

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$ 467.50
Cat# ALS10030
Availability: 5 days
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