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GPR3 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - GPR3 Antibody (Extracellular Domain) ALS10037
    Anti-GPR3 antibody ALS10037 IHC of human brain, neurons and glia.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P46089
Reactivity Human, Mouse, Hamster, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution IHC-P (6 µg/ml)
Additional Information
Gene ID 2827
Other Names G-protein coupled receptor 3, ACCA orphan receptor, GPR3, ACCA
Target/Specificity Human GPR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR3 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR3
Synonyms ACCA
Function Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)- coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye Highly expressed in regions of the brain implicated in the Alzheimer disease
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).

References

Song Z.-H.,et al.Genomics 28:347-349(1995).
Iismaa T.P.,et al.Genomics 24:391-394(1994).
Eggerickx D.,et al.Biochem. J. 309:837-843(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 467.50
Cat# ALS10037
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