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GPR44 / CRTH2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9Y5Y4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Dilution | IHC-P (15 µg/ml) |
| Gene ID | 11251 |
|---|---|
| Other Names | Prostaglandin D2 receptor 2, Chemoattractant receptor-homologous molecule expressed on Th2 cells, G-protein coupled receptor 44, CD294, PTGDR2, CRTH2, DL1R, GPR44 |
| Target/Specificity | Human GPR44 / CRTH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCNN2 (50%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR44 / CRTH2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTGDR2 |
|---|---|
| Synonyms | CRTH2, DL1R, GPR44 |
| Function | Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)- protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A. |
| Tissue Location | Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
References
Marchese A.,et al.Genomics 56:12-21(1999).
Nagata K.,et al.J. Immunol. 162:1278-1286(1999).
Methner A.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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