OPRD1 / Delta Opioid Receptor Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P41143 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 40kDa |
Dilution | IHC-P (32 µg/ml) |
Gene ID | 4985 |
---|---|
Other Names | Delta-type opioid receptor, D-OR-1, DOR-1, OPRD1, OPRD |
Target/Specificity | Human Delta Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ZC3H11A (44%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | OPRD1 / Delta Opioid Receptor Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | OPRD1 |
---|---|
Synonyms | OPRD |
Function | G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. |
Volume | 50 µl |
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Background
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
References
Knapp R.J.,et al.Life Sci. 54:PL463-PL469(1994).
Knapp R.J.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Simonin F.,et al.Mol. Pharmacol. 46:1015-1021(1994).
Kaighin V.A.,et al.Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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