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GPR37L1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O60883 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 9283 |
|---|---|
| Other Names | Prosaposin receptor GPR37L1, Endothelin B receptor-like protein 2, ETBR-LP-2, G-protein coupled receptor 37-like 1, GPR37L1, ETBRLP2 |
| Target/Specificity | Human GPR37L1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FOXR1 (50%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR37L1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR37L1 |
|---|---|
| Synonyms | ETBRLP2 |
| Function | G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250|UniProtKB:Q99JG2} |
| Tissue Location | Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.
References
Valdenaire O.,et al.FEBS Lett. 424:193-196(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
Halim A.,et al.J. Proteome Res. 12:573-584(2013).
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