|Dilution||IHC-P (10 µg/ml)|
|Other Names||Cysteinyl leukotriene receptor 2, CysLTR2, G-protein coupled receptor GPCR21, hGPCR21, G-protein coupled receptor HG57, HPN321, CYSLTR2, CYSLT2, CYSLT2R|
|Target/Specificity||Human CYSLTR2 / CYSLT2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CYSLT2 / CYSLTR2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Takasaki J.,et al.Biochem. Biophys. Res. Commun. 274:316-322(2000).
Heise C.E.,et al.J. Biol. Chem. 275:30531-30536(2000).
Nothacker H.-P.,et al.Mol. Pharmacol. 58:1601-1608(2000).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Kopatz S.A.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
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