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RXFP1/ LGR7 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9HBX9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87kDa |
| Dilution | IHC-P (12 µg/ml) |
| Gene ID | 59350 |
|---|---|
| Other Names | Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, RXFP1, LGR7 |
| Target/Specificity | Human RXFP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ANGPT2 (47%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | RXFP1/ LGR7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RXFP1 |
|---|---|
| Synonyms | LGR7 |
| Function | Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
References
Hsu S.Y.,et al.Mol. Endocrinol. 14:1257-1271(2000).
Muda M.,et al.Mol. Hum. Reprod. 11:591-600(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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