|Dilution||IHC-P (12 µg/ml)|
|Other Names||Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, RXFP1, LGR7|
|Target/Specificity||Human RXFP1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ANGPT2 (47%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||RXFP1/ LGR7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Hsu S.Y.,et al.Mol. Endocrinol. 14:1257-1271(2000).
Muda M.,et al.Mol. Hum. Reprod. 11:591-600(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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