|Reactivity||Human, Rabbit, Pig, Horse, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A, 220.127.116.11, PDE8A|
|Target/Specificity||Human PDE8A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||PDE8A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory- phosphorylation and stimulates RAF1-dependent EGF-activated ERK- signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).|
|Tissue Location||Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Wang P.,et al.Gene 280:183-194(2001).
Glavas N.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6319-6324(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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