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PDE3A Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q14432 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 125kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 5139 |
|---|---|
| Other Names | cGMP-inhibited 3', 5'-cyclic phosphodiesterase A, 3.1.4.17, Cyclic GMP-inhibited phosphodiesterase A, CGI-PDE A, PDE3A |
| Target/Specificity | Human PDE3A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except EDN3 (58%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | PDE3A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE3A (HGNC:8778) |
|---|---|
| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:8695850, PubMed:8155697, PubMed:25961942). Has also activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9Z0X4}; Multi- pass membrane protein. Cytoplasm, cytosol |
| Volume | 100 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
References
Meacci E.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:3721-3725(1992).
Liu H.,et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
Cheung P.P.,et al.Blood 88:1321-1329(1996).
Kuthe A.,et al.Chem. Biol. Interact. 119:593-598(1999).
Degerman E.,et al.Biochim. Biophys. Acta 1205:189-198(1994).
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