|Reactivity||Human, Rabbit, Bovine|
|Dilution||IHC-P (17 µg/ml)|
|Other Names||Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1|
|Target/Specificity||Human GRM1 / MGLUR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GRM1 / MGLUR1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890). May function in the light response in the retina (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in brain.|
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Desai M.A.,et al.Mol. Pharmacol. 48:648-657(1995).
Stephan D.,et al.Neuropharmacology 35:1649-1660(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Guergueltcheva V.,et al.Am. J. Hum. Genet. 91:553-564(2012).
Wu H.,et al.Science 344:58-64(2014).
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