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ADGRG2 / GPR64 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8IZP9 |
| Reactivity | Human, Mouse, Hamster, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 112kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 10149 |
|---|---|
| Other Names | G-protein coupled receptor 64, Human epididymis-specific protein 6, He6, GPR64, HE6, TM7LN2 |
| Target/Specificity | Human GPR64. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | ADGRG2 / GPR64 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRG2 {ECO:0000303|PubMed:25713288, ECO:0000312|HGNC:HGNC:4516} |
|---|---|
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta- hydroxyandrost-5-en-17-one) and androstenedione (PubMed:29393851, PubMed:35982227, PubMed:39884271). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:29393851). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:33303626, PubMed:34234254). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:29393851, PubMed:34234254). Also able to couple with G(q) G proteins in vitro (PubMed:29393851). Together with CFTR, required to promote fluid reabsorption within efferent ductule (PubMed:29393851). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein |
| Tissue Location | Epididymis-specific expression (at protein level). Both subunits are associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. Mainly expressed in the nonciliated principal cells of the proximal excurrent ducts Specifically over-expressed in Ewing sarcomas but also up-regulated in a number of carcinomas derived from prostate, kidney or lung |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
References
Osterhoff C.,et al.DNA Cell Biol. 16:379-389(1997).
Obermann H.,et al.Mol. Reprod. Dev. 64:13-26(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Olsen J.V.,et al.Sci. Signal. 3:RA3-RA3(2010).
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