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AGTR2 / AT2 Receptor Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P50052 |
| Reactivity | Human, Mouse, Hamster, Monkey, Pig, Sheep, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 186 |
|---|---|
| Other Names | Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2, AGTR2 |
| Target/Specificity | Human AGTR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR65 (63%), NPFFR2 (44%). |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | AGTR2 / AT2 Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGTR2 {ECO:0000303|PubMed:7790004, ECO:0000312|HGNC:HGNC:338} |
|---|---|
| Function | Receptor for angiotensin II, a vasoconstricting peptide (PubMed:28379944, PubMed:29967536, PubMed:31899086, PubMed:8185599). Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways (PubMed:28379944). Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (PubMed:15123706). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P35374}; Multi-pass membrane protein |
| Tissue Location | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
References
Martin M.M.,et al.Biochem. Biophys. Res. Commun. 209:554-562(1995).
Chassagne C.,et al.Genomics 25:601-603(1995).
Koike G.,et al.Biochem. Biophys. Res. Commun. 203:1842-1850(1994).
Tsuzuki S.,et al.Biochem. Biophys. Res. Commun. 200:1449-1454(1994).
Martin M.M.,et al.Biochem. Biophys. Res. Commun. 205:645-651(1994).
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