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CCR3 Antibody (Extracellular Domain)

Rabbit Polyclonal Antibody

     
  • IHC - CCR3 Antibody (Extracellular Domain) ALS10348
    Anti-CCR3 antibody ALS10348 IHC of human tonsil, lymphocytes.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P51677
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 1232
Other Names C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3
Target/Specificity Human CCR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCCR3 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR3
Synonyms CMKBR3
Function Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location In eosinophils as well as trace amounts in neutrophils and monocytes.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

References

Combadiere C.,et al.J. Biol. Chem. 270:16491-16494(1995).
Combadiere C.,et al.J. Biol. Chem. 270:30235-30235(1995).
Daugherty B.L.,et al.J. Exp. Med. 183:2349-2354(1996).
Ponath P.D.,et al.J. Exp. Med. 183:2437-2448(1996).
Xiao L.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.

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Discontinued
Cat# ALS10348
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