|Application ||IHC-P, E|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3|
|Target/Specificity||Human CCR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||CCR3 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064). Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064). In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||In eosinophils as well as trace amounts in neutrophils and monocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Combadiere C.,et al.J. Biol. Chem. 270:16491-16494(1995).
Combadiere C.,et al.J. Biol. Chem. 270:30235-30235(1995).
Daugherty B.L.,et al.J. Exp. Med. 183:2349-2354(1996).
Ponath P.D.,et al.J. Exp. Med. 183:2437-2448(1996).
Xiao L.,et al.Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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