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CASR/Calcium Sensing Receptor Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CASR/Calcium Sensing Receptor Antibody (N-Terminus) ALS10359
    Anti-CASR/Calcium Sensing Receptor antibody IHC of human kidney, diabetes.
    detail
  • IHC - CASR/Calcium Sensing Receptor Antibody (N-Terminus) ALS10359
    Anti-CASR antibody ALS10359 IHC of human parathyroid.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P41180
Reactivity Human, Mouse, Rabbit, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 121kDa
Dilution IHC-P (4-8 µg/ml)
Additional Information
Gene ID 846
Other Names Extracellular calcium-sensing receptor, CaSR, Parathyroid cell calcium-sensing receptor 1, PCaR1, CASR, GPRC2A, PCAR1
Target/Specificity Human CASR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCASR/Calcium Sensing Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASR (HGNC:1514)
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.

References

Pearce S.H.S.,et al.Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases.
Garrett J.E.,et al.J. Biol. Chem. 270:12919-12925(1995).
Aida K.,et al.Biochem. Biophys. Res. Commun. 214:524-529(1995).
Freichel M.,et al.Endocrinology 137:3842-3848(1996).
Aida K.,et al.J. Clin. Endocrinol. Metab. 80:2594-2598(1995).

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$ 467.50
Cat# ALS10359
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