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Leukotriene B4 Receptor / BLT1 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q15722 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 1241 |
|---|---|
| Other Names | Leukotriene B4 receptor 1, LTB4-R 1, LTB4-R1, Chemoattractant receptor-like 1, G-protein coupled receptor 16, P2Y purinoceptor 7, P2Y7, LTB4R, BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7 |
| Target/Specificity | Human Leukotriene B4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | Leukotriene B4 Receptor / BLT1 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTB4R |
|---|---|
| Synonyms | BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7 |
| Function | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
References
Akbar G.K.M.,et al.J. Biol. Chem. 271:18363-18367(1996).
Raport C.J.,et al.J. Leukoc. Biol. 59:18-23(1996).
Yokomizo T.,et al.Nature 387:620-624(1997).
Owman C.S.O.,et al.Genomics 37:187-194(1996).
Kato K.,et al.J. Exp. Med. 192:413-420(2000).
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