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ADGRF5 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8IZF2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 149kDa |
| Dilution | IHC-P (2-4 µg/ml) |
| Gene ID | 221395 |
|---|---|
| Other Names | Probable G-protein coupled receptor 116, GPR116, KIAA0758 |
| Target/Specificity | Human GPR116. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | ADGRF5 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRF5 (HGNC:19030) |
|---|---|
| Synonyms | GPR116, KIAA0758 |
| Function | Adhesion G protein-coupled receptor (PubMed:28570277). In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis (PubMed:28570277). Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation (PubMed:28570277). In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump (By similarity). As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue (PubMed:34016966). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in lung endothelial cells and in alveolar type II (ATII) cells (at protein level) (PubMed:23684610, PubMed:28570277). Expressed high levels in subcutaneous adipose tissue in lean individuals and at lower levels in visceral fat. Expression levels in subcutaneous adipose tissue drastically drop in obese individuals (PubMed:34016966). |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May have a role in the regulation of acid-base balance.
References
Fredriksson R.,et al.FEBS Lett. 531:407-414(2002).
Bonner T.I.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:355-364(1998).
Ohara O.,et al.Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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