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ADAMTS4 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O75173 |
| Reactivity | Human, Monkey, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 90kDa |
| Dilution | IHC-P (2.6 µg/ml) |
| Gene ID | 9507 |
|---|---|
| Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688 |
| Target/Specificity | Human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ADAMTS8 (53%). |
| Reconstitution & Storage | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
| Precautions | ADAMTS4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADAMTS4 |
|---|---|
| Synonyms | KIAA0688 |
| Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed in brain, lung and heart (PubMed:23897278). Expressed at very low level in placenta and skeletal muscles (PubMed:23897278). Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
References
Tortorella M.D.,et al.Science 284:1664-1666(1999).
Wainwright S.D.,et al.Matrix Biol. 25:317-320(2006).
Sawaji Y.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ishikawa K.,et al.DNA Res. 5:169-176(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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