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FFAR1 / GPR40 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O14842 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31kDa |
| Dilution | IHC-P (5-10 µg/ml) |
| Gene ID | 2864 |
|---|---|
| Other Names | Free fatty acid receptor 1, G-protein coupled receptor 40, FFAR1, GPR40 |
| Target/Specificity | Human GPR40. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | FFAR1 / GPR40 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FFAR1 |
|---|---|
| Synonyms | GPR40 |
| Function | G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain and pancreas. Detected in pancreatic beta cells. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.
References
Sawzdargo M.,et al.Biochem. Biophys. Res. Commun. 239:543-547(1997).
Briscoe C.P.,et al.J. Biol. Chem. 278:11303-11311(2003).
Tomita T.,et al.Biochem. Biophys. Res. Commun. 338:1788-1790(2005).
Sum C.S.,et al.J. Biol. Chem. 282:29248-29255(2007).
Sum C.S.,et al.J. Biol. Chem. 284:3529-3536(2009).
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