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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   ADGRG6 / GPR126 Antibody (C-Terminus)   

ADGRG6 / GPR126 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human liver.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human prostate.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-GPR126 antibody ALS10436 IHC of human brain, neurons and glia.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human Lung, Small Cell Carcinoma.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human Lung, Adenocarcinoma.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human Pancreas, Carcinoma.
    detail
  • IHC - ADGRG6 / GPR126 Antibody (C-Terminus) ALS10436
    Anti-DREG / GPR126 antibody IHC of human prostate, carcinoma.
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q86SQ4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 137kDa
Dilution IHC-P (3-5 µg/ml)
Additional Information
Gene ID 57211
Other Names G-protein coupled receptor 126, Developmentally regulated G-protein-coupled receptor, Vascular inducible G protein-coupled receptor, GPR126, DREG, VIGR
Target/Specificity Human GPR126. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsADGRG6 / GPR126 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADGRG6 (HGNC:13841)
Function Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP) (PubMed:35394864, PubMed:39884271). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:24227709, PubMed:35394864). ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:24227709, PubMed:35394864). Also able to couple to G(q) G proteins (PubMed:24227709). Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Also acts as a regulator of body length and bone mass (PubMed:18391950). Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Note=Detected on the cell surface of activated but not resting umbilical vein.
Tissue Location Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Orphan receptor. May be required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels (By similarity).

References

Stehlik C.,et al.FEBS Lett. 569:149-155(2004).
Moriguchi T.,et al.Genes Cells 9:549-560(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 467.50
Cat# ALS10436
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