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CRFR1 / CRHR1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P34998 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | IHC-P (13 µg/ml) |
| Gene ID | 1394 |
|---|---|
| Other Names | Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR |
| Target/Specificity | Human CRF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CRFR1 / CRHR1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRHR1 (HGNC:2357) |
|---|---|
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis |
| Tissue Location | Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
References
Chen R.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:8967-8971(1993).
Vita N.,et al.FEBS Lett. 335:1-5(1993).
Sakai K.,et al.Gene 219:125-130(1998).
Ross P.C.,et al.Biochem. Biophys. Res. Commun. 205:1836-1842(1994).
Grammatopoulos D.K.,et al.Mol. Endocrinol. 13:2189-2202(1999).
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