|Dilution||IHC-P (5 µg/ml)|
|Other Names||Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1|
|Target/Specificity||Human NUR77. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NR4A1 / NUR77 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GFRP1, HMR, NAK1|
|Function||Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Mitochondrion. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340) Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950)|
|Tissue Location||Fetal muscle and adult liver, brain and thyroid.|
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Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'- AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
Nakai A.,et al.Mol. Endocrinol. 4:1438-1443(1990).
Chang C.,et al.J. Steroid Biochem. 34:391-395(1989).
Ohkura N.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Kobayashi T.,et al.Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases.
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