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GPR80 / GPR99 / OXGR1 Antibody (Extracellular Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q96P68 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 27199 |
|---|---|
| Other Names | 2-oxoglutarate receptor 1, Alpha-ketoglutarate receptor 1, G-protein coupled receptor 80, G-protein coupled receptor 99, P2Y purinoceptor 15, P2Y15, P2Y-like GPCR, P2Y-like nucleotide receptor, OXGR1, GPR80, GPR99, P2RY15, P2Y15 |
| Target/Specificity | Human OXGR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR80 / GPR99 / OXGR1 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OXGR1 |
|---|---|
| Function | G protein-coupled receptor for dicarboxylates and amino dicarboxylates (PubMed:15141213, PubMed:36571463, PubMed:36919698). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11 and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation. Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). Receptor for alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis. In an intrarenal paracrine signaling pathway, binds alpha-ketoglutarate and drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity) (PubMed:15141213). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner |
| Tissue Location | Detected in kidney and, to a lower extent, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).
References
Lee D.K.,et al.Gene 275:83-91(2001).
Wittenberger T.,et al.BMC Genomics 3:17-17(2002).
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Bruess M.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
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