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GPR146 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q96CH1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37kDa |
| Dilution | IHC-P (14 µg/ml) |
| Gene ID | 115330 |
|---|---|
| Other Names | Probable G-protein coupled receptor 146, G-protein coupled receptor PGR8, GPR146, PGR8 |
| Target/Specificity | Human GPR146. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | GPR146 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR146 |
|---|---|
| Synonyms | PGR8 |
| Function | G-protein coupled receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor.
References
Vassilatis D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
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