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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   OPN5 Antibody (C-Terminus)   

OPN5 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - OPN5 Antibody (C-Terminus) ALS10528
    Anti-OPN5 antibody IHC of human Skin, Melanoma.
  • IHC - OPN5 Antibody (C-Terminus) ALS10528
    Anti-OPN5 antibody IHC of human Ovary, Carcinoma.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q6U736
Reactivity Human, Rabbit, Monkey, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 40kDa
Dilution IHC-P (16-32 µg/ml)
Additional Information
Gene ID 221391
Other Names Opsin-5, G-protein coupled receptor 136, G-protein coupled receptor PGR12, Neuropsin, Transmembrane protein 13, OPN5, GPR136, PGR12, TMEM13
Target/Specificity Human OPN5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsOPN5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPN5
Synonyms GPR136, PGR12, TMEM13
Function G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain and retina and cell lines derived from neural retina.
Volume 50 µl
Research Areas
Citations (0)

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References

Tarttelin E.E.,et al.FEBS Lett. 554:410-416(2003).
Fredriksson R.,et al.FEBS Lett. 554:381-388(2003).
Vassilatis D.K.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 467.50
Cat# ALS10528
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