|Dilution||IHC-P (15 µg/ml)|
|Other Names||Oxoeicosanoid receptor 1, 5-oxo-ETE G-protein coupled receptor, G-protein coupled receptor 170, G-protein coupled receptor R527, G-protein coupled receptor TG1019, OXER1, GPR170, TG1019|
|Target/Specificity||Human OXER1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MLEC (61%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||OXER1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)- hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
Hosoi T.,et al.J. Biol. Chem. 277:31459-31465(2002).
Jones C.E.,et al.Mol. Pharmacol. 63:471-477(2003).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
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