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TAAR6 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q96RI8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38kDa |
| Dilution | IHC-P (3-7 µg/ml) |
| Gene ID | 319100 |
|---|---|
| Other Names | Trace amine-associated receptor 6, TaR-6, Trace amine receptor 6, Trace amine receptor 4, TaR-4, TAAR6, TA4, TAR4, TRAR4 |
| Target/Specificity | Human TAAR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | TAAR6 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TAAR6 (HGNC:20978) |
|---|---|
| Function | Olfactory receptor specific for trace amines, such as beta- phenylethylamine (beta-PEA). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors. Beta- PEA-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed at low abundance in various brain tissues, as well as in fetal liver, but not in the cerebellum or placenta (PubMed:15329799). In the brain, comparable levels of expression in basal ganglia, frontal cortex, substantia nigra, amygdala and hippocampus, highest expression in hippocampus and lowest expression in basal ganglia (PubMed:15329799) |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood.
References
Borowsky B.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
Kopatz S.A.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Duan J.,et al.Am. J. Hum. Genet. 75:624-638(2004).
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