SLC5A10 / SGLT5 Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | A0PJK1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64kDa |
Dilution | IHC-P (20 µg/ml) |
Gene ID | 125206 |
---|---|
Other Names | Sodium/glucose cotransporter 5, Na(+)/glucose cotransporter 5, Solute carrier family 5 member 10, SLC5A10, SGLT5 |
Target/Specificity | Human SLC5A10. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SLC5A1 (67%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | SLC5A10 / SGLT5 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC5A10 |
---|---|
Synonyms | SGLT5 {ECO:0000303|PubMed:24573086} |
Function | [Isoform 1]: Electrogenic Na+-coupled sugar symporter that actively transports D-mannose or D-fructose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump. Exclusively recognizes sugar substrates having a pyranose ring with an axial hydroxyl group on carbon 2 (PubMed:24573086, PubMed:22212718, PubMed:23451068). Has likely evolved to enable renal reabsorption of D-mannose, an important constituent of oligosaccharide chains of glycoproteins. Contributes to dietary D-fructose reabsorption from glomerular filtrate across the brush border of the kidney (PubMed:22212718, PubMed:23451068). |
Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:Q5SWY8}; Multi-pass membrane protein |
Tissue Location | Predominantly expressed at high levels in kidney. Very low expression is detected in testes [Isoform 2]: The most abundant isoform expressed in kidney. [Isoform 5]: Expressed in kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mayya V.,et al.Sci. Signal. 2:RA46-RA46(2009).
Grempler R.,et al.FEBS Lett. 586:248-253(2012).
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