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PTPRM / PTP Mu Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P28827 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 164kDa |
| Dilution | IHC-P (15 µg/ml) |
| Gene ID | 5797 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase mu, Protein-tyrosine phosphatase mu, R-PTP-mu, 3.1.3.48, PTPRM, PTPRL1 |
| Target/Specificity | Human PTPRM. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | PTPRM / PTP Mu Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPRM |
|---|---|
| Synonyms | PTPRL1 |
| Function | Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Localizes in regions of cell- cell contact. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
References
Gebbink M.F.B.G.,et al.FEBS Lett. 290:123-130(1991).
Nusbaum C.,et al.Nature 437:551-555(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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