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CRHR2 / CRF2 Receptor Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q13324 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48kDa |
| Dilution | IHC-P (34 µg/ml) |
| Gene ID | 1395 |
|---|---|
| Other Names | Corticotropin-releasing factor receptor 2, CRF-R-2, CRF-R2, CRFR-2, Corticotropin-releasing hormone receptor 2, CRH-R-2, CRH-R2, CRHR2, CRF2R, CRH2R |
| Target/Specificity | Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | CRHR2 / CRF2 Receptor Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRHR2 |
|---|---|
| Synonyms | CRF2R, CRH2R |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
References
Liaw C.W.,et al.Endocrinology 137:72-77(1996).
Kostich W.A.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Kostich W.A.,et al.Mol. Endocrinol. 12:1077-1085(1998).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
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