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FZD10 / Frizzled 10 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9ULW2 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 65kDa |
| Dilution | IHC-P (6-16 µg/ml) |
| Gene ID | 11211 |
|---|---|
| Other Names | Frizzled-10, Fz-10, hFz10, FzE7, CD350, FZD10 |
| Target/Specificity | Human FZD10 / Frizzled 10. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | FZD10 / Frizzled 10 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FZD10 |
|---|---|
| Function | Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
References
Koike J.,et al.Biochem. Biophys. Res. Commun. 262:39-43(1999).
Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).
Kwon H.S.,et al.Mol. Cell. Biol. 29:2139-2154(2009).
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