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Ceramide Kinase / CERK Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - Ceramide Kinase / CERK Antibody (Internal) ALS10774
    Anti-CERK antibody ALS10774 IHC of human brain, cortex.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8TCT0
Reactivity Human, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 60kDa
Dilution IHC-P (20 µg/ml)
Additional Information
Gene ID 64781
Other Names Ceramide kinase, hCERK, 2.7.1.138, Acylsphingosine kinase, Lipid kinase 4, LK4, CERK, KIAA1646
Target/Specificity Human CERK. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCeramide Kinase / CERK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CERK
Synonyms KIAA1646
Function Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031). Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2- ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031). Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826). Binds phosphoinositides (PubMed:19168031).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein
Tissue Location High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

References

Sugiura M.,et al.J. Biol. Chem. 277:23294-23300(2002).
Van Veldhoven P.P.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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$ 467.50
Cat# ALS10774
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