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DUSP22 / JSP 1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9NRW4 |
| Reactivity | Human, Rabbit, Monkey, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21kDa |
| Dilution | IHC-P (4 µg/ml) |
| Gene ID | 56940 |
|---|---|
| Other Names | Dual specificity protein phosphatase 22, 3.1.3.16, 3.1.3.48, JNK-stimulatory phosphatase-1, JSP-1, Low molecular weight dual specificity phosphatase 2, LMW-DSP2, Mitogen-activated protein kinase phosphatase x, MAP kinase phosphatase x, MKP-x, DUSP22, JSP1, LMWDSP2, MKPX |
| Target/Specificity | Human DUSP22. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | DUSP22 / JSP 1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DUSP22 |
|---|---|
| Synonyms | JSP1, LMWDSP2, MKPX |
| Function | Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitous. Highest expression seen in heart, placenta, lung, liver, kidney and pancreas |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By similarity).
References
Shen Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:13613-13618(2001).
Gu J.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Mao Y.,et al.Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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