SLC5A6 / SMVT Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
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Primary Accession | Q9Y289 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 69kDa |
Dilution | IHC-P (5-10 µg/ml) |
Gene ID | 8884 |
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Other Names | Sodium-dependent multivitamin transporter, Na(+)-dependent multivitamin transporter, Solute carrier family 5 member 6, SLC5A6, SMVT |
Target/Specificity | Human SLC5A6. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | SLC5A6 / SMVT Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC5A6 (HGNC:11041) |
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Synonyms | SMVT |
Function | Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:21570947, PubMed:20980265, PubMed:22015582, PubMed:25971966, PubMed:25809983, PubMed:28052864, PubMed:27904971, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Preferentially localized at the luminal membrane of brain capillary endothelium (PubMed:25809983). Localized to the brush border/apical membrane of intestine and renal polarized cells (PubMed:19211916). |
Tissue Location | Expressed in microvessels of the brain (at protein level) (PubMed:25809983). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:10329687) |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transports pantothenate, biotin and lipoate in the presence of sodium.
References
Wang H.,et al.J. Biol. Chem. 274:14875-14883(1999).
Prasad P.D.,et al.Arch. Biochem. Biophys. 366:95-106(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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