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QSOX2 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q6ZRP7 |
| Reactivity | Human, Mouse, Monkey, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 78kDa |
| Dilution | IHC-P (20 µg/ml) |
| Gene ID | 169714 |
|---|---|
| Other Names | Sulfhydryl oxidase 2, 1.8.3.2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1, QSOX2, QSCN6L1, SOXN |
| Target/Specificity | Human QSOX2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | QSOX2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | QSOX2 |
|---|---|
| Synonyms | QSCN6L1, SOXN |
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. |
| Cellular Location | Membrane; Single- pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane |
| Tissue Location | Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.
References
Wittke I.,et al.Cancer Res. 63:7742-7752(2003).
Humphray S.J.,et al.Nature 429:369-374(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Daub H.,et al.Mol. Cell 31:438-448(2008).
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