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KCNH2 / HERG Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q12809 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 127kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 3757 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily H member 2, Eag homolog, Ether-a-go-go-related gene potassium channel 1, ERG-1, Eag-related protein 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, Voltage-gated potassium channel subunit Kv11.1, KCNH2, ERG, ERG1, HERG |
| Target/Specificity | Human KCNH2 / Kv11.1. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | KCNH2 / HERG Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNH2 (HGNC:6251) |
|---|---|
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Channel properties are modulated by cAMP and subunit assembly (PubMed:10837251). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612, PubMed:26363003, PubMed:27916661, PubMed:9230439, PubMed:9351446, PubMed:9765245). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (PubMed:10219239, PubMed:9230439). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
References
Warmke J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:3438-3442(1994).
Itoh T.,et al.Hum. Genet. 102:435-439(1998).
Soejima H.,et al.Genomics 74:115-120(2001).
Downie D.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
Crociani O.,et al.J. Biol. Chem. 278:2947-2955(2003).
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