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SRPX2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O60687 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 27286 |
|---|---|
| Other Names | Sushi repeat-containing protein SRPX2, Sushi-repeat protein upregulated in leukemia, SRPX2, SRPUL |
| Target/Specificity | Human SRPX2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SRPX2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SRPX2 |
|---|---|
| Synonyms | SRPUL |
| Function | Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. |
| Cellular Location | Secreted. Cytoplasm. Cell surface. Synapse |
| Tissue Location | Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
References
Kurosawa H.,et al.Blood 93:321-332(1999).
Huang C.-H.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Ross M.T.,et al.Nature 434:325-337(2005).
Roll P.,et al.Hum. Mol. Genet. 15:1195-1207(2006).
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