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HCRT / Orexin Antibody
Sheep Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, IHC-F |
|---|---|
| Primary Accession | O43612 |
| Reactivity | Human |
| Host | Sheep |
| Clonality | Polyclonal |
| Calculated MW | 13kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 3060 |
|---|---|
| Other Names | Orexin, Hypocretin, Hcrt, Orexin-A, Hypocretin-1, Hcrt1, Orexin-B, Hypocretin-2, Hcrt2, HCRT, OX, PPORX, PPOX |
| Target/Specificity | Specific for human orexin A. |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | HCRT / Orexin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HCRT (HGNC:4847) |
|---|---|
| Synonyms | OX, PPORX, PPOX |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. |
| Cellular Location | Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232} Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses {ECO:0000250|UniProtKB:O55232} |
| Tissue Location | Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
References
Sakurai T.,et al.Cell 92:573-585(1998).
Sakurai T.,et al.J. Biol. Chem. 274:17771-17776(1999).
Lee J.-H.,et al.Eur. J. Biochem. 266:831-839(1999).
Hungs M.,et al.Bioessays 23:397-408(2001).
Willie J.T.,et al.Annu. Rev. Neurosci. 24:429-458(2001).
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