RAD23A / HHR23A Antibody (aa122-135)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | P54725 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 40kDa |
Dilution | ELISA (1:4000-1:16000), IHC-P (5 µg/ml), WB (1:500-1:2000) |
Gene ID | 5886 |
---|---|
Other Names | UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A |
Target/Specificity | aa 122-135 of human HR23A protein. |
Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
Precautions | RAD23A / HHR23A Antibody (aa122-135) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAD23A |
---|---|
Function | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. |
Cellular Location | Nucleus. |
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Background
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
References
Masutani C.,et al.EMBO J. 13:1831-1843(1994).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Withers-Ward E.S.,et al.J. Virol. 71:9732-9742(1997).
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