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RAD23A / HHR23A Antibody (aa122-135)

Goat Polyclonal Antibody

     
  • IHC - RAD23A / HHR23A Antibody (aa122-135) ALS11349
    Anti-RAD23A / HHR23A antibody IHC of human prostate.
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  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P54725
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 40kDa
Dilution ELISA (1:4000-1:16000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 5886
Other Names UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A
Target/Specificity aa 122-135 of human HR23A protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsRAD23A / HHR23A Antibody (aa122-135) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAD23A
Function Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
Cellular Location Nucleus.
Research Areas
Citations (0)
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Background

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

References

Masutani C.,et al.EMBO J. 13:1831-1843(1994).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Withers-Ward E.S.,et al.J. Virol. 71:9732-9742(1997).

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Discontinued
Cat# ALS11349
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