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ACE2 / ACE-2 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IF - ACE2 / ACE-2 Antibody (Internal) ALS11371
    Immunofluorescence of ACE2 in Human Kidney cells with ACE2 antibody at 20 ug/ml.
  • WB - ACE2 / ACE-2 Antibody (Internal) ALS11371
    Western blot of ACE2 in human kidney lysate with ACE2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
  • IHC - ACE2 / ACE-2 Antibody (Internal) ALS11371
    Anti-ACE-2 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q9BYF1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 92kDa
Dilution IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 59272
Other Names Angiotensin-converting enzyme 2, 3.4.17.23, ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, ACEH, Metalloprotease MPROT15, Processed angiotensin-converting enzyme 2, ACE2
Target/Specificity synthetic peptide corresponding to amino acids near the center of human ACE2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsACE2 / ACE-2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACE2 (HGNC:13557)
Function Essential counter-regulatory carboxypeptidase of the renin- angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1- 9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042, PubMed:10924499, PubMed:11815627, PubMed:19021774, PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin (PubMed:10969042, PubMed:11815627). Also cleaves other biological peptides, such as apelins (apelin-13, [Pyr1]apelin-13, apelin-17, apelin-36), casomorphins (beta-casomorphin- 7, neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627, PubMed:27217402, PubMed:28293165). In addition, ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity (PubMed:18424768, PubMed:19185582).
Cellular Location [Processed angiotensin-converting enzyme 2]: Secreted
Tissue Location Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level) (PubMed:15141377). Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) (PubMed:15141377). Expressed in the renal proximal tubule and the small intestine (at protein level) (PubMed:18424768) Expressed in heart, kidney, testis, and gastrointestinal system (PubMed:10969042, PubMed:10924499, PubMed:15231706, PubMed:12459472, PubMed:15671045). In lung, expressed at high levels in secretory club and goblet cells as well as in alveolar type 2 cells (PubMed:32425701) Coexpressed with TMPRSS2 within lung alveolar type 2 cells, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (Ref.40, PubMed:32327758, PubMed:32358202). {ECO:0000269|PubMed:10924499, ECO:0000269|PubMed:10969042, ECO:0000269|PubMed:12459472, ECO:0000269|PubMed:15141377, ECO:0000269|PubMed:15231706, ECO:0000269|PubMed:15671045, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:32327758, ECO:0000269|PubMed:32358202, ECO:0000269|PubMed:32425701, ECO:0000269|Ref.40}
Research Areas
Citations (0)

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Background

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

References

Donoghue M.,et al.Circ. Res. 87:E1-E9(2000).
Tipnis S.R.,et al.J. Biol. Chem. 275:33238-33243(2000).
Douglas G.C.,et al.Endocrinology 145:4703-4711(2004).
Itoyama S.,et al.Am. J. Med. Genet. A 136:52-57(2005).
Suzuki Y.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS11371
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