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IKBKAP / IKAP Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | O95163 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 150kDa |
| Dilution | IHC-P (2.5 µg/ml), WB (0.5-1 µg/ml), |
| Gene ID | 8518 |
|---|---|
| Other Names | Elongator complex protein 1, ELP1, IkappaB kinase complex-associated protein, IKK complex-associated protein, p150, IKBKAP, ELP1, IKAP |
| Target/Specificity | 16 amino acid peptide from near the carboxy terminus of human IKAP |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | IKBKAP / IKAP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ELP1 (HGNC:5959) |
|---|---|
| Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059). |
| Cellular Location | Cytoplasm. Nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).
References
Cohen L.,et al.Nature 395:292-296(1998).
Slaugenhaupt S.A.,et al.Am. J. Hum. Genet. 68:598-605(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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