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GDF9 / GDF-9 Antibody (aa45-59)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60383 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | ELISA (1:1000), IHC-P (10 µg/ml), |
| Gene ID | 2661 |
|---|---|
| Other Names | Growth/differentiation factor 9, GDF-9, GDF9 |
| Target/Specificity | Amino acids 45 to 59 of human GDF9 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GDF9 / GDF-9 Antibody (aa45-59) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GDF9 |
|---|---|
| Function | Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
References
Schmutz J.,et al.Nature 431:268-274(2004).
Aaltonen J.,et al.J. Clin. Endocrinol. Metab. 84:2744-2750(1999).
Yamamoto N.,et al.J. Clin. Endocrinol. Metab. 87:2849-2856(2002).
Yamamoto N.,et al.J. Clin. Endocrinol. Metab. 87:4495-4495(2002).
McMahon H.E.,et al.Endocrinology 149:812-817(2008).
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