AICAR / ATIC Antibody (clone F38 P7 H9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P31939 |
Reactivity | Human, Rabbit, Monkey, Pig, Horse, Xenopus, Bovine, Dog, Drosophila |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | F38 P7 H9 |
Calculated MW | 65kDa |
Dilution | IHC-P (15 µg/ml) |
Gene ID | 471 |
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Other Names | Bifunctional purine biosynthesis protein PURH, Phosphoribosylaminoimidazolecarboxamide formyltransferase, 2.1.2.3, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase, IMP cyclohydrolase, 3.5.4.10, ATIC, IMP synthase, Inosinicase, ATIC, PURH |
Target/Specificity | ATIC |
Reconstitution & Storage | Store at 4°C. Do not freeze. |
Precautions | AICAR / ATIC Antibody (clone F38 P7 H9) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ATIC (HGNC:794) |
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Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6- mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113} |
Tissue Location | Present in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
References
Rayl E.A.,et al.J. Biol. Chem. 271:2225-2233(1996).
Yamauchi M.,et al.DNA Res. 2:269-275(1995).
Sugita T.,et al.J. Biochem. 122:309-313(1997).
Shichijo S.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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