TAAR1 / TA1 Antibody (aa225-250)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q96RJ0 |
Reactivity | Human, Rat, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 39kDa |
Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
Gene ID | 134864 |
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Other Names | Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1, TAAR1, TA1, TAR1, TRAR1 |
Target/Specificity | A portion of amino acids 225-250 of human TAAR1 |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | TAAR1 / TA1 Antibody (aa225-250) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TAAR1 |
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Synonyms | TA1, TAR1, TRAR1 |
Function | Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Detected in low levels in discrete regions within the central nervous system and in several peripheral tissues Moderately expressed in stomach. Low levels in amygdala, kidney, and lung, and small intestine. Trace amounts in cerebellum, dorsal root ganglia, hippocampus, hypothalamus, liver, medulla, pancreas, pituitary, pontine reticular formation, prostate, skeletal muscle and spleen |
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Background
Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
References
Borowsky B.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
Bunzow J.R.,et al.Mol. Pharmacol. 60:1181-1188(2001).
Kopatz S.A.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Lindemann L.,et al.Genomics 85:372-385(2005).
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